Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities
نویسندگان
چکیده
منابع مشابه
Polyhydroxylated indolizidine alkaloids-synthesis of dideoxycastanospermine
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متن کاملPolyhydroxylated indolizidine alkaloidsdsynthesis of dideoxycastanospermine
Powered by TCPDF (www.tcpdf.org) This material is protected by copyright and other intellectual property rights, and duplication or sale of all or part of any of the repository collections is not permitted, except that material may be duplicated by you for your research use or educational purposes in electronic or print form. You must obtain permission for any other use. Electronic or print cop...
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Recently, we have enatiospeciflcally synthesized nagstatin (1) and its analogs (for example, 2) having different configurations and functionalities and clarified the structure-activity relationships2 ~ 4). Herein, we describe the synthesis of the triazole analogs (3 and 4) having a triazole ring in place of an imidazole ring, and evaluate their glycosidase inhibitory activities to better unders...
متن کاملSynthesis and glycosidase-inhibitory activity of novel polyhydroxylated quinolizidines derived from D-glycals.
A number of structurally novel polyhydroxylated quinolizidines have been prepared starting from 2-deoxyglycosylamines which in turn were derived from D-glycals by following a methodology developed in our laboratory. In our strategy, Grignard reaction and ring-closing metathesis (RCM) reactions are the key steps to construct the desired skeletons. All synthesized final molecules were checked for...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2010
ISSN: 0040-4020
DOI: 10.1016/j.tet.2010.10.008